Postdoctoral Fellow or Staff Scientist - Protein Chemistry, Crystallography and Structure Determination

City of Hope

Duarte, CA

Job posting number: #7227047 (Ref:10025182)

Posted: March 11, 2024

Application Deadline: Open Until Filled

Job Description

Thank you for your interest. Please note, the purpose of this posting is to recruit for on-going and future positions.

Join the forefront of groundbreaking research at the Beckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research.

The John Williams research lab at City of Hope is seeking a Postdoctoral Fellow or a Staff Scientist to join an innovative team. Our research primarily focuses on structural and biophysical methods to identify sources of energy additivity and multivalency in macromolecular complexes and use these properties to develop new tools and novel therapeutics.

As a successful candidate, you will:

· Determine structure of modified antibodies with immune receptors

· Apply yeast display to stabilize and subsequent deimmunize proteases

· Create additional antibody variants to maximize the therapeutic activity in a clinical setting

Your qualifications should include:

· Ph.D. degree chemistry, biochemistry, structural biology, biophysics or a related discipline is required.

· Knowledge of protein engineering (cloning, expression, purification), crystallography (crystallization, optimization, data collection and structure determination), biochemistry (enzyme kinetics) and biophysics (Surface Plasmon Resonance, Iosthermal Ttitration Calorimetry

Additional Information:

· To apply to the position, please send your CV or resume to Dr. John Williams at [email protected] for consideration.

· Candidates will be assessed for the suitable level based on their relevant experience.

· Postdoctoral Fellow - Pay Rate: $34.00 – $37.54

· Staff Scientist – Pay Rate: $38.67 – $123.37

City of Hope is an equal opportunity employer. To learn more about our commitment to diversity, equity, and inclusion, pleaseclick here.

The estimated pay scale represents the typical [salary/hourly] range City of Hope reasonably expects to pay for this position, with offers determined based on several factors which may include, but not be limited to, the candidate’s experience, expertise, skills, education, job scope, training, internal equity, geography/market, etc. This pay scale is subject to change from time to time.

City of Hope is a community of people characterized by our diversity of thought, background and approach, but tied together by our commitment to care for and cure those with cancer and other life-threatening diseases. The innovation that our diversity produces in the areas of research, treatment, philanthropy and education has made us national leaders in this fight. Our unique and diverse workforce provides us the ability to understand our patients' needs, deliver compassionate care and continue the quest for a cure for life-threatening diseases. At City of Hope, diversity and inclusion is a core value at the heart of our mission. We strive to create an inclusive workplace environment that engages all of our employees and provides them with opportunities to develop and grow, both personally and professionally. Each day brings an opportunity to strengthen our work, leverage our different perspectives and improve our patients’ experiences by learning from others. Diversity and inclusion is about much more than policies and campaigns. It is an integral part of who we are as an institution, how we operate and how we see our future.

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