Post Doctoral Associate

University of Pittsburgh

Pennsylvania, Pittsburgh

Job posting number: #7156736 (Ref:23000177)

Posted: June 21, 2023

Application Deadline: Open Until Filled

Job Description


Postdoc position for cancer genetics, cancer cell biology/immunobiology, and computational genomics

Degree Requirements: Ph.D. is required in Molecular Biology

A postdoc position is available at Wang Laboratory of the UPMC Hillman Cancer Center, in the Department of Pathology, University of Pittsburgh. The individual will be working on our leading-edge integrative genomics initiatives aimed at identifying pathological genetic aberrations and immunological targets from multi-dimensional cancer genomics datasets. The candidate will receive unique multidisciplinary training in cancer genetics, cancer cell biology, immunobiology, computational genomics, and translational research. The candidate must hold a Ph.D. degree. A preference will be given to highly motivated candidates with an outstanding publication record in cancer research, and those with established expertise in cancer cell biology or immunobiology.

The research project for this position will interface the “dark side” of cancer genetics with cancer pathobiology and immunobiology. Specifically, the candidate will investigate a cryptic class of adjacent gene rearrangements in more aggressive and therapy-resistant forms of breast and/or ovarian cancers, and examine their function in cancer progression and/or immunotherapy resistance. The primary responsibilities will include experimental validation of newly discovered genetic targets, characterizing their molecular basis, elucidating their clinical significance using patient samples, confirming their role in tumor progression, immune dysfunction, or therapy resistance in vitro and/or in vivo, pinpointing their mechanistic basis, and exploring potential clinical applications.

Wang laboratory is a translational cancer research lab at UPMC Hillman Cancer Center, Department of Pathology, University of Pittsburgh. Our lab is dedicated to the discovery and characterization of novel breast cancer genetic targets from multi-dimensional genomic datasets to achieve precision therapeutics. Our research projects have been funded by four awards from NIH/NCI, four awards from the Department of Defense, two awards from Susan G. Komen Foundation, as well as Nancy Owens Breast Cancer Foundation, Commonwealth of PA, and PA breast cancer coalition, and our studies have led to high-profile publications in Nature Biotechnology, Nature Communications, PNAS, Cancer Discovery, Cancer Research, and Clinical Cancer Research, etc. Our postdoc trainees have received four prestigious postdoc fellowship Awards including two awards from the Susan G. Komen Foundation and two awards from the Department of Defense.

As our major achievements, our lab has identified two recurrent gene fusions ESR1-CCDC170 and BCL2L14-ETV6 in luminal B and triple-negative breast cancer, respectively -- the only two canonical gene fusions identified in major breast cancer entities to date. In addition, our lab has characterized two breast cancer kinase targets, NLK and TLK2, and preformed preclinical studies of their inhibitors. Our computational genomics research focuses on precision oncology and immuno-oncology. We have developed an innovative integral genomic signature approach for tailored cancer therapy using genome-wide sequencing data. We also developed an integrated HEPA-PARSE approach for the high-throughput identification of tumor-associated antigen targets. Our research projects are backed up by top-notch research facilities, vast clinical sample repositories, and first-class computational infrastructure at UPMC and the University of Pittsburgh. For more information, please visit

To apply, please use the application form below and upload a combined pdf file containing your CV, cover letter, and the contact information of 3 referees. Review of applications will begin immediately until these positions are filled. The University of Pittsburgh offers a comprehensive salary program and excellent benefits in a smoke and drug free workplace. University of Pittsburgh School of Medicine is an Affirmative Action/Equal Opportunity Employer and encourages applications from under-represented groups.

Xiaosong Wang, M.D., Ph.D.

Associate Professor of Pathology

UPMC Hillman Cancer Center

Email: [email protected]


The University of Pittsburgh is committed to championing all aspects of diversity, equity, inclusion, and accessibility within our community. This commitment is a fundamental value of the University and is crucial in helping us advance our mission, which includes attracting and retaining diverse workforces. We will continue to create and maintain an environment that allows individuals to discover, belong, contribute, and grow, while honoring the experiences, perspectives, and unique identities of all.

 The University of Pittsburgh is an Affirmative Action/Equal Opportunity Employer and values equality of opportunity, human dignity and diversity. EOE, including disability/vets. The University of Pittsburgh requires all Pitt constituents (employees and students) on all campuses to be vaccinated against COVID-19 or have an approved exemption. Visit to learn more about this requirement. 

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Job posting number:#7156736 (Ref:23000177)
Application Deadline:Open Until Filled
Employer Location:University of Pittsburgh
United States
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