A postdoctoral associate position is available for highly motivated candidates in the laboratory of Dr. Bokai Zhu at the Aging Institute of the University of Pittsburgh School of Medicine. The Zhu lab studies the regulation and function of dynamic proteostasis and metabolism, with a focus on the intriguing 12h ultradian rhythm of mRNA, protein, and lipid metabolism.

The search is primarily targeted toward scientists who recently finished their Ph.D., particularly researchers with a passion in systemic and quantitative chronobiology, cell biology, metabolism and endocrinology, neurodegenerative diseases, molecular biology, gene regulation, and epigenetics. In addition, we welcome candidates from other research backgrounds (such as immunology) and/or different using different research models (such as C. elegans) to join. Expertise in any of the following areas is highly valued:

• In vivo mouse circadian and hepatic metabolism techniques, including IP and tail vein injection techniques, CLAMS system to study energy expenditure, and various metabolic phenotyping.

• Experiences in using iPSC to study the cellular basis of neurodegenerative diseases, experiences with mouse models of Tau and/or Aβ neuropathology.

• Molecular biology, biochemistry, and experiences in the field of transcriptional regulation of gene expression, biomolecule condensates, functional genomics, chromatin biology, epigenetics, with expertise in performing ChIP/CUT&RUN assay, generating and analyzing next-generation sequencing datasets, etc.

 • Cell biology with expertise in quantitative imaging such as fluorescence time-lapse microscopy, super-resolution microscopy, and image analysis.

• In vivo mouse circadian and hepatic metabolism techniques, including IP and tail vein injection techniques, CLAMS system to study energy expenditure, and various metabolic phenotyping.

• Experiences in using iPSC to study the cellular basis of neurodegenerative diseases, experiences with mouse models of Tau and/or Aβ neuropathology.

• Molecular biology, biochemistry, and experiences in the field of transcriptional regulation of gene expression, biomolecule condensates, functional genomics, chromatin biology, epigenetics, with expertise in performing ChIP/CUT&RUN assay, generating and analyzing next-generation sequencing datasets, etc.

 • Cell biology with expertise in quantitative imaging such as fluorescence time-lapse microscopy, super-resolution microscopy, and image analysis.

Qualifications: A Ph.D. (awarded in the last 5 years) or MD (awarded in the last 10 years) in biological science, life science, or a related field is required.

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