Biophotonics in Yun Lab at MGH, Harvard Medical School

Wellman Center, Massachusetts General Hospital

Cambridge, MA

Job posting number: #7146811

Posted: May 24, 2023

Salary / Pay Rate: 60,000-80,000

Application Deadline: Open Until Filled

Job Description

PI: Seok Hyun Andy Yun

We are currently seeking highly motivated and talented graduate students and postdoctoral researchers, as well as a technician, to join our dynamic team at Yun Lab.

Ideal postdoctoral candidates should have a solid publication record in relevant fields, such as physics, chemistry, bioengineering, and possess excellent communication skills and a strong work ethic.

To apply, please submit a comprehensive CV and a cover letter to Prof. Yun at [email protected]. Recommendation letters are not required for initial inquiries but will be necessary for full consideration.

Project 1: Microfluidic Sorting of Multicolor Laser Particles and Their Applications

The Yun Lab has pioneered the development of Laser Particles (LPs), semiconductor nanoparticles that emit single-mode laser spectra. We are currently exploring their innovative applications in life sciences. LPs offer bright, spectrally narrowband emissions, making them suitable for use as cellular barcodes and building blocks for multiplexed bead assays. We are looking for a highly motivated and capable researcher for a project with three specific aims:

1. Build a microfluidic sorter for selecting LPs with specific spectra or sorting cells containing certain LPs.
2. Fabricate a large color palette of LPs using the sorting instrument.
3. Apply multi-color LPs for multiplexed assays.

The ideal candidate should have experience in constructing microfluidic and optical systems and working with cells and biological samples.

Project 2: Multidimensional Single-Cell Analysis from Live Imaging to Sequencing

Funded by the NIH Director's Transformative Award, this project aims to advance single-cell analysis through novel cell-barcoding technologies. The project's primary goal is to move beyond static analysis by incorporating additional dimensions, such as spatiotemporal changes and cell interactions. We are developing innovative DNA-optical barcodes that enable time-lapse live-cell imaging and high-throughput single-cell sequencing, which can then be aligned to the same cells unambiguously according to their individual cell barcodes.

The ideal candidate should have a strong interest in pioneering research, new technologies, and demonstrated expertise in cellular experiments and sequencing and imaging data analysis.

Project 3: Optical Coherence Elastography

We have an open position in our NIH-funded project focused on developing optical coherence elastography to measure the mechanical properties and tension in the cornea. This project involves both technological development and clinical studies involving participants with various corneal conditions.

The ideal candidate should be familiar with continuum mechanics and finite element computer simulation, capable of modifying and operating optical instruments, and interested in applying advanced instruments to obtain and analyze data from human studies.

In addition, we welcome applications from exceptional candidates eager to explore new ideas and projects. For instance, we are particularly interested in the development and applications of Brillouin microscopy, as well as innovative light sources, such as nanolasers.

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