Postdoctoral Associate- Cellular Heterogeneity and Circuit Organization of Brains

Baylor College of Medicine

Houston, TX

Job posting number: #7145926 (Ref:15796-en_US)

Posted: May 19, 2023

Application Deadline: Open Until Filled

Job Description


The Jiang laboratory in the Departments of Neuroscience at Baylor College of Medicine is seeking applicants for postdoc associate positions. The specific goal of the postdoc fellows for these positions is to use a multi-disciplinary approach, including single-cell transcriptomics, Patch-seq, multi-patch clamp recording, machine learning, and complicated genetic tools to understand cellular heterogeneity and circuit organization of healthy and diseased brains. The fellows will use rodent and primate models, including surgically resected human tissue, to understand brain cell types with the molecular, spatial, and morpho-electric annotations, and how genetic lesions (related to epilepsy and autism) give rise to culprit cell types that contribute to the core symptoms of the diseases.

You can learn more about our research at, or from recent publications in our labs:

Jiang X., Shen S., Cadwell C.R., Berens P., Sinz F., Ecker A.S., Tolias A.S. (2015). Principles of Connectivity among Morphologically Defined Cell Types in Adult Neocortex. Science. Vol. 350 no. 6264 DOI: 10.1126
Cadwell CR, Palasantza A, Jiang X, Berens P, Deng Q, Yilmaz M, Reimer J, Shen S, Bethge M, Tolias KF, Sandberg R & Tolias AS (2016). Morphological, electrophysiological, and transcriptomic profiling of single neurons using Patch-seq. Nature Biotechnology, 34(2), 199-203. doi: 10.1038/nbt.3445. Epub 2015 Dec 21.
Scala F, Kobak D, Shan S, Bernaerts Y, Laturnus S, Cadwell CR, Hartmanis H, Castro J, Tan ZH, Sandberg S, Berens P, Jiang X*, Tolias AT*. Layer 4 of mouse neocortex differs in cell types and circuit organization between sensory areas. Nature Communication. volume 10, Article number: 4174 (2019) *co-corresponding authors
McKinney A, Hu M, Hoskins A, Mohammadyar A, Naeem N, Jing J, Patel S, Sheth RB. Jiang X. Cellular composition and circuit organization of the locus coeruleus in adult mice. Elife. 2023 Feb 3;12:e80100.
Shen S, Scala F, Reimer J, Fu J, Fahey P, Sinz. F, Jiang X#, Tolias AS. Distinct organization of two cortico-cortical feedback pathways. Nature Communication, 2022 Oct 27;13(1):6389. #*co-corresponding authors

Jing J, Hu M, Ngodup T, Ma Q, Lau, SNN, Ljungberg C, McGinley MJ, Trussell LO, Jiang X. (2023). Comprehensively Defining Cellular Specializations for Initiating Parallel Auditory Pathways in the Mouse Cochlear Nucleus. bioRxiv. 

Job Duties

  • Uses single-nucleus RNA-sequencing, Patch-seq, multi-patching electrophysiology, and other molecular techniques on brain tissue to decipher and define cellular constituents of cortical circuits with molecular, morpho-electric, spatial, and functional annotations in the primate and rodent brain.
  • Probes and defines the cellular constituents of brain circuits associated with epilepsy and autism.
  • Performs rigorous and well-controlled experiments as well as data analysis.
  • Summarizes research findings, publish results in research journals, and presentation of research results at professional conferences.

Minimum Qualifications

  • MD or Ph.D. in Basic Science, Health Science, or a related field.
  • No experience required.

Preferred Qualifications

  • Experience with patch-clamp electrophysiology.
  • Excellent written/oral communication and organizational skills are required, and work effectively in a team environment.
  • Experience with single-cell RNA-seq, bioinformatics analysis, and molecular techniques.



Baylor College of Medicine requires employees to be fully vaccinated -subject to approved exemptions-against vaccine-preventable diseases including, but not limited to, COVID-19 and influenza.


Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.



Baylor College of Medicine fosters diversity among its students, trainees, faculty and staff as a prerequisite to accomplishing our institutional mission, and setting standards for excellence in training healthcare providers and biomedical scientists, promoting scientific innovation, and providing patient-centered care. - Diversity, respect, and inclusiveness create an environment that is conducive to academic excellence, and strengthens our institution by increasing talent, encouraging creativity, and ensuring a broader perspective. - Diversity helps position Baylor to reduce disparities in health and healthcare access and to better address the needs of the community we serve. - Baylor is committed to recruiting and retaining outstanding students, trainees, faculty and staff from diverse backgrounds by providing a welcoming, supportive learning environment for all members of the Baylor community.

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