Postdoctoral Research Fellow: Alternative Splicing in Pancreatic Cancer Metastasis
H. Lee Moffitt Cancer Center
Tampa, FL
Job posting number: #7126275 (Ref:63213)
Posted: February 23, 2023
Application Deadline: Open Until Filled
Job Description
At Moffitt Cancer Center, we come face-to-face with cancer every day, but we also see courage. And it inspires us to be the safest and best place for cancer care – to bring greater hope to every patient we serve. It’s why we’ve been continually named One of the Top Places to Work in the Tampa Bay Area. As the only National Cancer Institute-designated Comprehensive Cancer Center based in Florida, Moffitt employs some of the best and brightest minds from around the world. Moffitt is the leading cancer hospital in both Florida and the Southeast and has been nationally ranked by U.S. News & World Report since 1999. Because working at Moffitt is both a career and a mission: to contribute to the prevention and cure of cancer. Join a dedicated, diverse and inclusive team of over 7,000 to be a part of the Courageous future we envision.
Summary
Postdoctoral Research Fellow: Alternative Splicing in Pancreatic Cancer Metastasis
About the Lab:
The Mann lab investigates the genetic and epigenetic regulation of novel tumor suppressors involved in the initiation and progression of pancreatic cancer (PDAC) that we discovered using an in vivo forward genetic screen. We are focused on the regulation of alternative splicing regulated by RBFOX2 during PDAC progression and how to leverage this splicing regulation to predict and prevent recurrent disease and/or metastatic progression. We are looking for an individual excited by inter-disciplinary approaches to investigate PDAC splicing signatures using ex vivo models, mouse models and patient samples with the goal of identifying additional splicing regulators and/or splicing events that may be explored for diagnostic or therapeutic efficacy to better treat cancer patients. More information about the lab can be viewed on our website http://labpages2.moffitt.org/mann_k.
Position Highlight:
A successful applicant will use molecular biology, genomics and proteomics to dissect the regulation of alternative splicing in PDAC and to study the functions of alternative spliced isoforms of key molecules that modulate cellular processes and signaling pathways driving pancreatic cancer development and metastasis. This individual will work both independently and collaboratively and will be part of a team that consists of basic researchers, clinicians and computational biologists.
The Ideal Candidate:
- Has a strong foundation in molecular biology and cancer biology
- Is experienced in mammalian cell culture, including ex vivo assays to assess phenotypic changes
- A background in alternative splicing and/or pancreatic cancer is highly desired
- Mouse genetics experience and familiarity with NGS is desired but not essential
Responsibilities:
- Learn research techniques that directly relate to the program’s scientific projects and goals with appropriate direction and supervision.
- Plan, conduct and document experiments independently; evaluate and interpret data with guidance.
- Develop scientific writing and presentation skills, including grant proposals, manuscript preparation and formal seminars presented to the Moffitt scientific community and at national scientific meetings.
Credentials and Qualifications:
PhD in Genetics, Molecular Biology, Biochemistry or related discipline earned within the last two years.
A competitive salary and benefits package will be offered to the successful candidate. Interested applicants should send a single PDF file that includes a current CV with recent publications, a personal statement of scientific interests and goals (2-page maximum) and contact information for three references to Dr. Karen Mann at [email protected].
Mission To create a Moffitt culture of diversity and inclusion as we strive to contribute to the prevention and cure of cancer. Vision Moffitt Cancer Center is recognized as the model wherein the diversity of our employees and communities is valued and supported as essential components to contributing to the prevention and cure of cancer. The cancer center is an equal opportunity employer. It is the policy of the cancer center to prohibit unlawful discrimination and harassment of any type and to afford equal employment opportunities to workforce members and applicants, regardless of race, color, religion, sex, sexual orientation, gender identity or expression, national origin, age, marital status, disability, genetic information, veteran’s status or any other characteristic protected by federal, state or local law.