Postdoctoral Appointee - Synthetic Biology for Development of Anti-Infectives

Sandia National Laboratories

Albuquerque, NM

Job posting number: #7125172 (Ref:688379)

Posted: February 16, 2023

Application Deadline: April 14, 2023

Job Description

Posting Duration
This posting will be open for application submissions for a minimum of seven (7) calendar days, including the ‘posting date’. Sandia reserves the right to extend the posting date at any time.

NNSA Requirements for MedPEDs
If you have a Medical Portable Electronic Device (MedPED), such as a pacemaker, defibrillator, drug-releasing pump, hearing aids, or diagnostic equipment and other equipment for measuring, monitoring, and recording body functions such as heartbeat and brain waves, if employed by Sandia National Laboratories you may be required to comply with NNSA security requirements for MedPEDs.

If you have a MedPED and you are selected for an on-site interview at Sandia National Laboratories, there may be additional steps necessary to ensure compliance with NNSA security requirements prior to the interview date.

What Your Job Will Be Like
Do you want to perform creative research that addresses major challenges such as public health, biosecurity, and energy security? Sandia/California’s Systems Biology Department is seeking a synthetic biology postdoctoral appointee to join a multidisciplinary team using molecular, synthetic, and computational biology methods to discover the design rules governing heterologous production of infection-disrupting antibodies/nanobodies (Abs/Nbs) in the respiratory tract! The selected applicant will help develop a new enabling technology platform for mRNA-instructed production of anti-infectives in vivo. The work will involve design and construction of Ab/Nb expression cassette libraries, introduction of the libraries into mammalian cells, screening of the cells for expression and secretion of Abs/Nbs, and Next Generation Sequencing (NGS) to identify sequences that promote/hinder Ab/Nb expression and secretion. There are additional opportunities to engage in mRNA delivery research, mouse biology, bioinformatics, and artificial intelligence and machine learning (AI/ML) tools, depending on interests. The individual selected will work at Sandia's Livermore campus and interact with a multidisciplinary project team, including scientists at universities.

On any given day, you may be called on to:

Develop and apply laboratory methodologies for genetic engineering of mammalian cells
Design and perform experiments to study heterologous production of Abs/Nbs by mammalian cells in vitro and in vivo
Analyze large data sets, including NGS, flow cytometry, high-content imaging, and high-throughput histology data sets
Mentor technologists and interns
Work collaboratively to design, implement, track, and refine project plans with an integrated multidisciplinary team that may include members from national labs, universities, and industry
Communicate your research through writing scientific papers, publishing in peer-reviewed journals, and presenting findings at seminars and conferences
Contribute to the creation and development of new scientific research proposals
Qualifications We Require
Recent PhD in Biology, Molecular Biology, Synthetic Biology, Systems Biology, or a related field
Proven record of high technical accomplishment and written communication (e.g., as evidenced by publication in high-impact scientific journals) and/or strong verbal communication and data presentation skills (e.g., as demonstrated through scientific conference presentations)
Qualifications We Desire
Molecular/synthetic biology skills, especially engineering heterologous protein production by mammalian cells
Experience with mRNA production for transforming mammalian cells
A strong background in synthetic and/or systems biology
Knowledge/experience with mouse biology, respiratory pathogens, and/or tissue analysis
Bioinformatics skills, especially familiarity with software tools for genomic analysis and/or command line programming skills
About Our Team
The Systems Biology Department, located in Livermore, California, is a diverse research group with a focus on both basic and applied biological research. We seek to address problems with strong ties to national security, including biodefense and health security, and climate and energy security. We do this using innovative research approaches in microbiology, virology, synthetic biology, immunology, and bioinformatics, incorporating advanced technology development including CRISPR/Cas technologies, advanced ‘omics, and advanced materials and nanotechnology. We also seek to develop the knowledge and technologies needed to produce clean, efficient, and cost-effective biofuels and other bioproducts on a commercial scale. Our department is part of the highly multidisciplinary Applied Biosciences and Engineering Group, comprised of researchers with expertise in many disciplines of biology (molecular biology, microbiology, virology, immunology, and biochemistry), chemistry (analytical, organic, and physical), computational science (bioinformatics, machine learning, and computational chemistry), and engineering (chemical, mechanical, and biomedical).

About Sandia
Sandia National Laboratories is the nation’s premier science and engineering lab for national security and technology innovation, with teams of specialists focused on cutting-edge work in a broad array of areas. Some of the main reasons we love our jobs:

Challenging work with amazing impact that contributes to security, peace, and freedom worldwide
Extraordinary co-workers
Some of the best tools, equipment, and research facilities in the world
Career advancement and enrichment opportunities
Flexible work arrangements for many positions include 9/80 (work 80 hours every two weeks, with every other Friday off) and 4/10 (work 4 ten-hour days each week) compressed workweeks, part-time work, and telecommuting (a mix of onsite work and working from home)
Generous vacations, strong medical and other benefits, competitive 401k, learning opportunities, relocation assistance and amenities aimed at creating a solid work/life balance*
World-changing technologies. Life-changing careers. Learn more about Sandia at:
*These benefits vary by job classification.

Security Clearance
This position does not currently require a Department of Energy (DOE) security clearance.

Sandia will conduct a pre-employment drug test and background review that includes checks of personal references, credit, law enforcement records, and employment/education verifications. Furthermore, employees in New Mexico need to pass a U.S. Air Force background screen for access to Kirtland Air Force Base. Substance abuse or illegal drug use, falsification of information, criminal activity, serious misconduct or other indicators of untrustworthiness can cause access to be denied or terminated, resulting in the inability to perform the duties assigned and subsequent termination of employment.

If hired without a clearance and it subsequently becomes necessary to obtain and maintain one for the position, or you bid on positions that require a clearance, a pre-processing background review may be conducted prior to a required federal background investigation. Applicants for a DOE security clearance need to be U.S. citizens. If you hold more than one citizenship (i.e., of the U.S. and another country), your ability to obtain a security clearance may be impacted.

Members of the workforce (MOWs) hired at Sandia who require uncleared access for greater than 179 days during their employment, are required to go through the Uncleared Personal Identity Verification (UPIV) process. Access includes physical and/or cyber (logical) access, as well as remote access to any NNSA information technology (IT) systems. UPIV requirements are not applicable to individuals who require a DOE personnel security clearance for the performance of their SNL employment or to foreign nationals. The UPIV process will include the completion of a USAccess Enrollment, SF-85 (Questionnaire for Non-Sensitive Positions) and OF-306 (Declaration of for Federal Employment). An unfavorable UPIV determination will result in immediate retrieval of the SNL issued badge, removal of cyber (logical) access and/or removal from SNL subcontract. All MOWs may appeal the unfavorable UPIV determination to DOE/NNSA immediately. If the appeal is unsuccessful, the MOW may try to go through the UPIV process one year after the decision date.

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, or veteran status and any other protected class under state or federal law.

Position Information
This postdoctoral position is a temporary position for up to one year, which may be renewed at Sandia's discretion up to five additional years. The PhD must have been conferred within five years prior to employment.

Individuals in postdoctoral positions may bid on regular Sandia positions as internal candidates, and in some cases may be converted to regular career positions during their term if warranted by ongoing operational needs, continuing availability of funds, and satisfactory job performance.

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or veteran status.

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Job posting number:#7125172 (Ref:688379)
Application Deadline:2023-4-14
Employer Location:Sandia National Laboratories
Albuquerque,New Mexico
United States
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