Postdoctoral Fellow

City of Hope

Duarte, CA

Job posting number: #7116955 (Ref:10018491)

Posted: November 30, 2022

Application Deadline: Open Until Filled

Job Description

About City of Hope

City of Hope is an independent biomedical research and treatment organization for cancer, diabetes, and other life-threatening diseases.

Founded in 1913, City of Hope is a leader in bone marrow transplantation and immunotherapy such as CAR T cell therapy. City of Hope’s translational research and personalized treatment protocols advance care throughout the world. Human synthetic insulin, monoclonal antibodies and numerous breakthrough cancer drugs are based on technology developed at the institution.  AccessHope™, a subsidiary launched in 2019 serves employers and their health care partners by providing access to City of Hope’s specialized cancer expertise.

A National Cancer Institute-designated comprehensive cancer center and a founding member of the National Comprehensive Cancer Network, City of Hope is ranked among the nation’s “Best Hospitals” in cancer by U.S. News & World Report and received Magnet Recognition from the American Nurses Credentialing Center. Its main campus is located near Los Angeles, with additional locations throughout Southern California and in Arizona.

City of Hope’s commitment to Diversity, Equity, and Inclusion

We believe diversity, equity and inclusion is key in serving our mission to provide compassionate patient care, drive innovative discovery, and advance vital education focused on eliminating cancer and diabetes in all our communities.  Our commitment to Diversity, Equity and Inclusion ensures we bring the full range of skills, perspectives, cultural backgrounds, and experiences to our work -- and that our teams align with the people we serve to build trust and understanding.  We are dedicated to fostering a community that embraces diversity - in ideas, backgrounds, and perspectives; this is reflected in our work and represented in our people.

Position Summary

A Postdoctoral Fellowship opportunity is immediately available for the highly motivated individual in the laboratory of Dr. June-Wha Rhee in City of Hope’s Department of Medicine, Division of Cardiology.

The lab’s research focuses on understanding the biology underlying cancer therapy-induced cardiovascular complications by leveraging human-induced pluripotent stem cells (iPSCs) as well as patient samples, genomics and leading-edge computational biology.

There has been remarkable progress in cancer treatments resulting in improved long-term survival. However, cardiovascular complications related to these therapies can cause treatment interruptions and lead to worse oncologic and cardiovascular outcomes. Therefore, there is a critical need to better understand 1) why and through what mechanisms the cancer therapy-related cardiotoxicity occurs, 2) who is at risk and 3) how to mitigate or prevent this toxicity. Our lab is working toward addressing these questions so that cancer patients can safely be treated with life-saving cancer therapies. Specifically, we believe metabolism and biologic aging are critical in modulating this risk and are working to define their roles by leveraging genome editing technology, multi-omics and advanced bioinformatics utilizing patient-specific iPSCs and patient samples.

The goal of the Rhee Lab is to pioneer basic and translational research in cardio-oncology so that we can find a way to protect our cancer patients from any cardiovascular complications. For this, we will employ cutting-edge technologies, bioinformatics, and patient-specific stem cells.

The candidate will investigate molecular mechanisms of cancer therapy-induced cardiotoxicity, leveraging cutting-edge computational biology, genome editing technologies, and induced pluripotent stem cell models.

Basic education, experience and skills required for consideration:

  • PhD or M.D. in molecular biology, genetics, biochemistry, cell biology, bioinformatics or related field
  • Previous experience in iPSC and/or mouse models, cardiovascular biology, molecular biology, genetics, or bioinformatics is highly desired but not required.

Additional Information:

As a condition of employment, City of Hope requires staff to comply with all state and federal vaccination mandates.

  • For more information on Dr. June Rhee’s lab please visit here

City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer.  All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.

City of Hope is a community of people characterized by our diversity of thought, background and approach, but tied together by our commitment to care for and cure those with cancer and other life-threatening diseases. The innovation that our diversity produces in the areas of research, treatment, philanthropy and education has made us national leaders in this fight. Our unique and diverse workforce provides us the ability to understand our patients' needs, deliver compassionate care and continue the quest for a cure for life-threatening diseases. At City of Hope, diversity and inclusion is a core value at the heart of our mission. We strive to create an inclusive workplace environment that engages all of our employees and provides them with opportunities to develop and grow, both personally and professionally. Each day brings an opportunity to strengthen our work, leverage our different perspectives and improve our patients’ experiences by learning from others. Diversity and inclusion is about much more than policies and campaigns. It is an integral part of who we are as an institution, how we operate and how we see our future.

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