Senior Scientist, Conjugation

Pfizer Inc.

Pearl River, NY

Job posting number: #7114486 (Ref:4862767)

Posted: October 24, 2022

Application Deadline: Open Until Filled

Job Description

Why Patients Need You

Pfizer’s purpose is to deliver breakthroughs that change patients’ lives. Research and Development is at the heart of fulfilling Pfizer’s purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most.

Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

Role Summary

As a Senior Scientist, Conjugation in the Early Bioprocess Development within Pfizer Vaccine Research and Development, you will be at the center of our operations and you’ll find that everything we do, every day, is in line with an unwavering commitment to quality.

You will join a large team of Scientists focused on conjugation process development for manufacturing carbohydrate-based conjugate vaccines. Primary duties include development of new/novel conjugation methods, analysis of glycoconjugates, and optimization of conjugation process parameters including conjugation and purification.

Role Responsibilities

Develop, optimize and scale-up conjugation process for glycoconjugate vaccine candidates.
Independently plan and execute experiments for conjugate vaccine candidates, and lead the development on special projects, when required.
Present periodic status updates to the group, discuss problems and propose solutions in discussion with group members. Offer insights based on experience to group members to help solve problems.
Collaborate with colleagues within Vaccine Research and Development organization including Bioprocess Fermentation, Purification, Analytical, and Formulation Development groups.
Keep abreast of scientific/technological development by participating in scientific meetings/seminars and through regular scientific review. Utilize new technologies and establish those technologies to improve conjugation process.
Continuously evaluate each process and technique to determine if it is robust, appropriate, and scalable. If an operation has shortcomings or can be improved, uses expertise and imagination to suggest improvements.
Participate in the technology transfer of developed process to the clinical manufacturing site, both internally and externally, and provide the technical support as needed.
Fully document laboratory experiments in electronic notebook in a timely and compliant manner and prepare technical reports as needed.
BASIC QUALIFICATIONS

MS degree in Chemistry with minimum of 7 years relevant carbohydrate experience.
Experiences with conjugation, purification processes and glycoconjugate analytical techniques are highly desirable.
Understanding of the design, planning, and execution of conjugation and purification activities including the operation and maintenance of relevant instruments, resolution of technical problems related to instruments, and execution of analytical/biophysical characterization methods.
Experience with a variety of state-of-the-art analytical techniques including NMR, Mass Spectrometry etc. and other analytical techniques.
Independently analyze and provide conclusions regarding experimental data generated.
Proficiency with personal computers including word processing, spreadsheets, PowerPoint, and relevant scientific software is desirable.
Strong verbal and written communication skills are required.
Experience with documentation of laboratory notebook in an electronic format.
PREFERRED QUALIFICATIONS

PhD degree in Organic Chemistry/Carbohydrate Chemistry or Biochemistry

PHYSICAL/MENTAL REQUIREMENTS

Standard laboratory conditions – sitting, standing, primarily lab based

40 hours per week

Relocation support available

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.


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