Postdoctoral Associate- Structural Biology and Crystallography

Baylor College of Medicine

Houston, TX

Job posting number: #7113082 (Ref:13413-en_US)

Posted: October 12, 2022

Application Deadline: Open Until Filled

Job Description


The Center for Drug Discovery ( is a strategic research center established at Baylor College of Medicine (BCM) in Houston, Texas. The mission of the Center for Drug Discovery is to establish novel discovery technologies that enable rapid and cost-effective drug discovery within the academic community. We are seeking highly skilled and motivated postdocs with expertise in biochemistry & crystallography to join the Center for Drug Discovery. Central to our vision is the continued establishment of a small-molecule discovery platform using a DNA-encoded chemistry approach. 


The team, led by scientists with drug discovery experience in academia and the pharmaceutical and biotech industry, is looking to recruit a postdoc. BCM is located in the world-renowned Texas Medical Center and offers a highly interactive environment and a strong infrastructure for research and career development. 

Job Duties

  • Participates in early stage drug discovery efforts in collaboration with biological  and chemical scientists throughout the academic community, with a goal of bringing new treatments to patients with unmet medical needs.
  • Contributes to multidisciplinary lead-finding project teams by engaging in the following activities: production, purification, and/or testing of recombinant proteins:  screening of DNA-encoded chemical libraries; evaluation of compounds for efficacy in vitro (biochemical and cell-based assays) and in vivo; structural biology; x-ray crystallography.
  •  Performs protein production and purification, molecular biology and vector construction, X-ray crystallography.


Minimum Qualifications

  • MD or Ph.D. in Basic Science, Health Science, or a related field.
  • No experience required.

Preferred Qualifications

  • PhD in biochemistry/structural biology or a related discipline,
  • Expertise in biochemistry, recombinant protein production/purification, biochemical assay methodologies, molecular biology and/or crystallography.
  • SF9 expression experience and core crystallography expertise including data processing, structure solution, refinement and analysis.
  • Works & communicates effectively in a team environment.



Baylor College of Medicine requires employees to be fully vaccinated -subject to approved exemptions-against vaccine-preventable diseases including, but not limited to, COVID-19 and influenza.


Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.



Baylor College of Medicine fosters diversity among its students, trainees, faculty and staff as a prerequisite to accomplishing our institutional mission, and setting standards for excellence in training healthcare providers and biomedical scientists, promoting scientific innovation, and providing patient-centered care. - Diversity, respect, and inclusiveness create an environment that is conducive to academic excellence, and strengthens our institution by increasing talent, encouraging creativity, and ensuring a broader perspective. - Diversity helps position Baylor to reduce disparities in health and healthcare access and to better address the needs of the community we serve. - Baylor is committed to recruiting and retaining outstanding students, trainees, faculty and staff from diverse backgrounds by providing a welcoming, supportive learning environment for all members of the Baylor community.

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Job posting number:#7113082 (Ref:13413-en_US)
Application Deadline:Open Until Filled
Employer Location:Baylor College of Medicine
United States
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