Postdoctoral Scientist (Computational research experience) - Anastassiou Lab - Department of Neurosurgery

Cedars-Sinai Medical Center

Los Angeles, CA

Job posting number: #7106730 (Ref: HRC0599973B)

Posted: July 26, 2022

Application Deadline: Open Until Filled

Job Description

If you're ready to be a part of breakthrough research, then we invite you to consider this exciting opportunity and apply today!

Principal Investigator, Costas Anastassiou, PhD, is seeking a Postdoctoral Scientist to join the team!

The Anastassiou Laboratory is affiliated with the Department of Neurosurgery and Neurology, the Center of Neural Sciences and Medicine and the Regenerative Medicine Institute. The lab team studies how the molecular and cellular composition of neurons translates to their phenotype and how these properties combine in brain circuits to produce function or, in the case of disease, dysfunction. The Anastassiou lab has broad background in multi-modal cellular data (electrophysiology, anatomy, transcriptomics) and the development of state-of-the-art computational workflows (statistical learning, optimization and simulation) to understand cellular activity in behavior and disease. The team employs multi-modal single-cell investigations in human circuits to understand cortical function and dysfunction as occurring in diseases like epilepsy.

In this role, you will be working independently but in close cooperation and in consultation on the team of Costas Anastassiou, PhD. You will perform routine and complex laboratory procedures throughout training period. You may develop, adapt, and implement new research techniques and protocols. You are also expected to analyze/interpret data and may assist in the preparation of grant proposals. This position participates in publications and presentations as author or co-author. This role is not be responsible for generating grant funds.

Additionally, you will be an essential team member in our ongoing effort to understand how electric fields affect cellular and circuit as well as the development of novel brain stimulation protocols. The core responsibility is to set-up computational simulations and data analysis workflows from slice and in vivo brain physiology in humans.

More specifically, the incumbent will be responsible for:

  • Designs and conducts biophysical simulations with an existing computational framework allowing simulation of reconstructed, interconnected, and biophysically realistic human neurons (e.g. [Reimann, Anastassiou et al, Neuron, 2013; Nandi et al, bioarxiv, 2020]).
  • Analyzes simulated and experimental data using state-of-the-art statistical analysis to understand cellular and circuit entrainment to fields.
  • Compares computational findings with experimental observables to deduce biophysical principles of high-level functioning.


Primary Job Duties and Responsibilities:

  • Designs and performs experiments; will keep appropriate experimental records and documentation and analyze the results with the Principal Investigator.
  • Analyzes, interprets, summarizes and compiles data.
  • Operates and maintains equipment and instruments.

Department-Specific Duties and Responsibilities:

  • In close collaboration with theoreticians and experimental colleagues, design, implement and conduct single-neuron and network simulations of human neurons and electric fields.
  • Contribute to ongoing efforts in computational framework development (simulation and data analysis) as well as to scientific questions relevant to the system under investigation.
  • Contribute to adjacent projects related to human pathophysiology and neurotherapies.
  • Publish/present findings in peer-reviewed journals/scientific conferences.
  • Prepare written and oral reports on a regular basis.
  • Maintain clear and accurate communication with supervisor, team members and external collaborators.



  • Doctorate (MD, PhD, VMD or DDS) in area directly related to field of research specialization, required.
  • Doctorate degree in Computational Neuroscience, Physics, Applied Mathematics, Bioengineering or related field, highly preferred.

Experience and Skillset:

  • Strong background in scientific computing; experience in computational neuroscience is preferred.
  • Acquires strong technical and theoretical knowledge of research project and objectives during one to five (1-5) year post-doctoral appointment.
  • Ability to meet aggressive timelines and deliverables in a collaborative environment.
  • Strong publication record.
  • Experience in pursuing research projects in collaborative fashion.
  • Proven independent thinking and flexibility.
  • Strong written and verbal communication skills.


  • Working Title: Postdoctoral Scientist (Computational research experience) - Anastassiou Lab - Department of Neurosurgery
  • Department: Home Dept-Black
  • Business Entity: Academic / Research
  • City: Los Angeles
  • Job Category: Academic/Research
  • Job Specialty: Postdoctoral
  • Position Type: Full-time
  • Shift Length: 8 hour shift
  • Shift Type: Day

Cedars-Sinai is an EEO employer. Cedars-Sinai does not unlawfully discriminate on the basis of the race, religion, color, national origin, citizenship, ancestry, physical or mental disability, legally protected medical condition (cancer-related or genetic characteristics or any genetic information), marital status, sex, gender, sexual orientation, gender identity, gender expression, pregnancy, age (40 or older), military and/or veteran status or any other basis protected by federal or state law. If you need a reasonable accommodation for any part of the employment process, please contact us by email at [email protected] and let us know the nature of your request and your contact information. Requests for accommodation will be considered on a case-by-case basis. Please note that only inquiries concerning a request for reasonable accommodation will be responded to from this email address.

Cedars-Sinai will consider for employment qualified applicants with criminal histories, in accordance with the Los Angeles Fair Chance Initiative for Hiring.

At Cedars-Sinai, we are dedicated to the safety, health and wellbeing of our patients and employees. This includes protecting our patients from communicable diseases, such as influenza (flu) and COVID-19. For this reason, we require that all new employees receive a flu vaccine based on the seasonal availability of flu vaccine (typically during September through April each year) as a condition of employment, and annually thereafter as a condition of continued employment, subject to medical exemption or religious accommodation. For the same reason, you may also be required to receive other vaccines such as COVID-19 as a condition of employment. Cedars-Sinai reserves the right to make modifications to its required list of vaccines as required by law and/or policy.

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