The Department of Laboratory Medicine at the Cleveland Clinic is currently seeking an Associate Director of Bioinformatics within the Molecular Pathology and Cytogenomics Section. We are seeking a PhD or MD/PhD with expertise in bioinformatics and genomics to support our growing Section's clinical and research needs. The position is a full-time clinical Professional Staff appointment; academic appointment through the Cleveland Clinic Lerner College of Medicine is available and encouraged. Working closely with the Bioinformatics Director, the Section Head and medical directors, the successful candidate will work collaboratively to support the development and maintenance of the data analytic and bioinformatics and reporting infrastructure, required to support our continued expansion of next generation sequencing and other high complexity assays within molecular genetics, oncology and hematopathology.

The successful candidate will spend the majority of their effort in clinical endeavors. Clinical responsibilities can include development and maintenance of bioinformatics pipelines and complex workflows (alignment, variant calling, variant annotation, copy number analysis, gene fusion, etc.), validation and documentation of bioinformatics pipelines, algorithms and tools in compliance with clinical accreditation requirements (i.e., CAP), development and implementation of applications to support variant annotation and report generation to streamline clinical data review and reporting, and integration of various data resources to support clinical workflows. The candidate would be expected to support the bioinformatics component of the clinical NGS workflow, provide technical expertise to assist in clinical review of assay quality metrics, results and other workflow troubleshooting, provide bioinformatics data analyses, summaries and visualizations for quality management, as well as work in collaboration with institutional IT and computing personnel to maintain NGS server hardware and software.

Although the majority of the candidate's efforts will be in clinical operations, participation in activities that support Cleveland Clinic's educational and research mission is encouraged and expected. There are multiple opportunities for research within clinical and anatomic pathology, including new efforts in Pathology AI, as well as across other clinical disciplines. Further research opportunities exist in projects involving data mining, analysis, and visualization of large-scale integrated data sets from genomic and clinical sources.

Candidates must have a PhD in Computational Biology, Biomedical Informatics, Data Science, Bioinformatics, Genomics, or a closely related discipline. It is strongly preferred that candidates have a minimum of one year of post-doctoral research or equivalent experience in an academic or clinical setting. Preference will be given to candidates with previous experience building bioinformatics algorithms and pipelines for processing genomic data, database development, and those who have worked in a CAP/CLIA accredited clinical laboratory setting. Broad experience in computational bioinformatics including Perl/Python programming, experience in Linux/Unix working environments, shell scripting, SQL (Structure Query Language), web-application development, as well as familiarity with various open source and commercial bioinformatics resources/software for NGS data analysis and variant annotation is desired. Ideally, the candidate will have experience using HPC or similar resources for high throughput computing. The candidate should demonstrate excellent communication and collaboration skills.

A faculty appointment at a rank commensurate with experience is available at Cleveland Clinic Lerner College of Medicine at Case Western Reserve University.

For more information, contact Elizabeth Azzato, MD, PhD, Section Head of Molecular Pathology and Cytogenomics Staff

([email protected], 216-444-8116)

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