Postdoctoral Fellow – DNA Metabolism in Cancer, Aging and Immunity
Job posting number: #7091928 (Ref:10014291)
Posted: January 11, 2022
Application Deadline: Open Until Filled
About City of Hope
City of Hope, an innovative biomedical research, treatment and educational institution with over 6000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.
Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation’s leading cancer centers that develops and institutes standards of care for cancer treatment.
Postdoctoral positions are now available in the laboratory of Dr. Yilun Liu at the Department of Cancer Genetics and Epigenetics, Beckman Research Institute of City of Hope. Dr. Liu’s research topics include
- dissecting the molecular mechanism by which cells prevent the formation of cancer-causing genomic instability as a consequence of conflicts between RNA transcription and DNA replication
- developing pharmaceutical mechanisms for cancer therapy by targeting enzymes important for preventing the formation of DNA breaks arose during accelerated cell growth such as in cancer cells as well as factors important for the BRCA2 and PARP-dependent repair pathways to keep these DNA breaks unrepaired
- exploring the role of mitochondrial DNA in cancer pathogenesis and in immune response
- targeting SUMOylation of topoisomerase I in chemo- and immuno-therapies.
Basic education, experience and skills required for consideration:
- A Ph.D. degree in life or biomedical sciences, or a related discipline is required.
- Experience in biochemistry and/or cell biology is preferred
- To protect the health of patients and staff and to comply with new State of California mandates, City of Hope staff are required to show proof of full vaccination by September 30, 2021. Compliance is a condition of employment.
- Dr. Liu’s research is currently supported by NIH R01 grants from National Cancer Institute (NCI) and National Institute of General Medical Science (NIGMS) and a grant from Pancreatic Cancer Action Network.
- Dr. Liu’s group has published in journals, including Nature Communications, Cell Reports, EMBO Journal and PNAS. A full list of publications can be found at
My Bibliography or Google Scholar.
- For more information on Dr. Liu’s research please visit, here.
- To protect the health of patients and staff and to comply with new State of California mandates, City of Hope staff are required to show proof of full COVID-19 vaccination. Compliance is a condition of employment.
City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.
City of Hope is a community of people characterized by our diversity of thought, background and approach, but tied together by our commitment to care for and cure those with cancer and other life-threatening diseases. The innovation that our diversity produces in the areas of research, treatment, philanthropy and education has made us national leaders in this fight. Our unique and diverse workforce provides us the ability to understand our patients' needs, deliver compassionate care and continue the quest for a cure for life-threatening diseases. At City of Hope, diversity and inclusion is a core value at the heart of our mission. We strive to create an inclusive workplace environment that engages all of our employees and provides them with opportunities to develop and grow, both personally and professionally. Each day brings an opportunity to strengthen our work, leverage our different perspectives and improve our patients’ experiences by learning from others. Diversity and inclusion is about much more than policies and campaigns. It is an integral part of who we are as an institution, how we operate and how we see our future.