Postdoctoral Fellow - Antibody Engineering for Cancer Therapy

City of Hope

Duarte, CA

Job posting number: #7091925 (Ref:10014719)

Posted: January 11, 2022

Application Deadline: Open Until Filled

Job Description

About City of Hope

City of Hope, an innovative biomedical research, treatment and educational institution with over 6000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.

Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research.  City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation’s leading cancer centers that develops and institutes standards of care for cancer treatment.

Position Summary

A Postdoctoral Fellow position is immediately available the department partment of Immunology and Theranostics at the Beckman Research Institute at City of Hope.

Dr. Yazaki's research focuses on the development of novel antibody-based molecules for the imaging and therapy of cancer. The scope includes recombinant antibodies, antibody fragments, fusion proteins, nanoparticles, conjugation chemistry, animal models, PET and NIR fluorescence imaging, radioimmunotherapy, photodynamic therapy, cGMP manufacture and translation into the clinic. 

This postdoctoral project offer specialized training in protein design, cloning, expression, purification, biophysical characterization, preclinical animal models, radionuclide/optical imaging and therapy and translation to first-in man clinical studies.

Postdoctoral Fellows are expected to be capable of working rigorously and independently to drive their projects to success. Communication skills (oral and written) are key, and the postdoctoral researcher is expected to present results at professional society conferences and prepare first-author papers each year.  City of Hope provide strong support for scientific writing and presentations (abstracts, manuscripts, grant applications and other materials) and offer guidance and opportunities for mentoring (i.e. training graduate students), all in a rich research environment with expertise in antibody engineering, molecular imaging, immunology, and translational sciences for postdocs who want to pursuit a career in academia or industry.

Basic education, experience and skills required for consideration:

  • Ph.D in Life or Biological Sciences and/or related field.
  • Strong background in antibody engineering.
  • Experience in protein design, molecular biology, biochemistry, animal models and/or immunology. 

Additional Information:

  • For more information on Dr. Paul Yazaki’s research, please visit here: here.
  • To protect the health of patients and staff and to comply with new State of California mandates, City of Hope staff are required to show proof of full vaccination by September 30, 2021.  Compliance is a condition of employment.  

City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer.  All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.



City of Hope is a community of people characterized by our diversity of thought, background and approach, but tied together by our commitment to care for and cure those with cancer and other life-threatening diseases. The innovation that our diversity produces in the areas of research, treatment, philanthropy and education has made us national leaders in this fight. Our unique and diverse workforce provides us the ability to understand our patients' needs, deliver compassionate care and continue the quest for a cure for life-threatening diseases. At City of Hope, diversity and inclusion is a core value at the heart of our mission. We strive to create an inclusive workplace environment that engages all of our employees and provides them with opportunities to develop and grow, both personally and professionally. Each day brings an opportunity to strengthen our work, leverage our different perspectives and improve our patients’ experiences by learning from others. Diversity and inclusion is about much more than policies and campaigns. It is an integral part of who we are as an institution, how we operate and how we see our future.

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