Postdoctoral Fellow – Modeling Cancer in Human Organ Chips

The Wyss Institute for Biologically Inspired Engineering at Harvard University

Boston, MA

Job posting number: #7091439

Posted: January 6, 2022

Application Deadline: Open Until Filled

Job Description

About the Wyss:

The mission of the Wyss Institute for Biologically Inspired Engineering at Harvard University is to transform human healthcare and the environment by emulating the way nature builds. Developed as an alliance between Harvard and other premier academic and clinical partner institutions, Institute faculty and staff collaborate in high-risk, fundamental research and science-driven technology development. A major focus of the Institute is to translate the technologies developed by its faculty and staff into commercial products and therapies through collaborations with clinical investigators and establishment of corporate alliances.

Role Description:

The Wyss Institute for Biologically Inspired Engineering at Harvard University invites applications for a postdoctoral fellow position in the Biomimetic Microsystems platform. We seek outstanding postdoctoral applicants with expertise and knowledge of cancer biology to join an interdisciplinary team of biologists and engineers for the development of novel in vitro human organ-on-chip microsystems technologies to study and model cancer growth, metastasis, and cancer drug discovery.

Our current efforts on the Cancer Research UK Grand Challenge are focused on the study of inflammation-associated cancers arising from IBD or Barrett’s Esophagus. We are investigating how chronic inflammation promotes cancer formation and what role the stromal microenvironment plays in this process. The goal to identify pathways and therapeutics that normalize the microenvironment to prevent or revert inflammation-associated cancer progression. The Ingber Lab is also leveraging organs-on-chip technology to create novel diagnostics that can prospectively identify patients with chronic inflammation whose lesions have a high risk of becoming cancerous.

What You’ll need:

Ph.D. and/or M.D.
Proven record of high-quality publications in the field of cancer biology
Advanced Cell Biology background
Strong interest in contributing to multidisciplinary teams (engineers, biologists/physiologists, clinicians) is critical for this position
Expertise in working with different types of cancer, 2D/3D in vitro cancer cell culture as well as knowledge of basic molecular and cell biology concepts and techniques is a must
Experience with primary cells and tissue is preferred


Strong expertise in cancer biology with an interest in applying this expertise in combination with modern bioengineering practices by leveraging human organ-on-a-chip technology in vitro
This postdoctoral fellow is expected to develop and lead an interdisciplinary research project aimed at creating microengineered organ-on-chip models, simulating human cancer growth and metastasis in different organs and exploring their use in drug discovery applications.

Benefits and Perks:

Medical/Dental/Vision: We offer a variety of excellent medical, dental, & vision plans. All coverage begins as of your start date.
Time Off: 20 days of vacation per year
Tuition Assistance Program: Competitive tuition assistance program, classes at the Harvard Extension School and discounted options through participating Harvard grad schools.
Transportation: Harvard offers a 50% discounted MBTA pass as well as additional options to assist employees in their daily commute.
Wellness Options: Harvard offers programs and classes at little or no cost, including stress management, nutrition, meditation, and complimentary health services.

Where You Can Apply:

Applications, assembled as single PDF files, should contain a complete resume, cover letter describing research interests and goals, full list of publications, copies of up to three relevant scientific papers, as well as the names and contact information of three references (expected to provide letters of recommendation). Applications should be sent to [email protected] using the subject line “CANCER BIOLOGY POSTDOCTORAL FELLOW APPLICATION.”

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