Postdoctoral Fellow - Immunotherapy for Oncogenic Herpesvirus
Job posting number: #7090669 (Ref:10014429)
Posted: January 17, 2022
Application Deadline: Open Until Filled
About City of Hope
City of Hope, an innovative biomedical research, treatment and educational institution with over 6,000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.
Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation’s leading cancer centers that develops and institutes standards of care for cancer treatment.
The Beckman Research Institute of City of Hope is looking for a talented Postdoctoral Fellow.
Our laboratory invites highly motivated candidates to apply for an interdisciplinary postdoctoral scholar position. Our laboratory focuses on oncogenic herpesviruses, in particular Epstein-Barr virus (EBV), Kaposi-sarcoma associated herpesvirus (KSHV), and the rhesus macaque EBV homologue rhesus lymphocryptovirus (rhLCV), and on developing prophylactic and therapeutic strategies against primary infection with these viruses and their associated cancers. The postdoctoral scholar will be working on projects with the overarching goal of designing and testing gamma herpesvirus vaccine candidates and immuno-therapeutics in various preclinical animal models.
The scholar will be leading projects that are in collaborations between the City of Hope Cancer Center and other institutions within and outside the USA. Importantly, City of Hope has good laboratory practice (GLP) and Current Good Manufacturing Practice (cGMP) FDA-approved biologic facilities (https://www.cityofhope.org/research/biological-and-cellular-gmp-manufacturing-facility/cbg---center-for-biomedicine-and-genetics) to produce the candidate vaccines and immunotherapeutics in house and test them in preclinical animal models and in Phase I clinical trials.
Basic education, experience and skills required for consideration:
- A Ph.D. degree in life or biomedical sciences, or a related discipline is required.
- Molecular biology, protein expression, purification, crystallization, and functionalization
- Generation and characterization of monoclonal antibodies for diagnostic and therapeutic purposes
- In vitro methods for assessing immunological responses, particularly antibody assays (such as ELISA, isolation/depletion of antigen-specific antibodies, viral neutralization assays, etc), T cell response and toxicity assays.
- In vivo immunization and/or tumor investigations, specifically murine (transgenic and humanized), rabbit and NHP models.
- Ability to design and execute laboratory experiments, critically interpret experimental results, and present data in a clear and concise manner
- Ability to participate in the preparation of grant applications, scientific publications and investigational new drug applications
- For more information about Ogembo’s lab, please visit https://www.cityofhope.org/research/beckman-research-institute/research-departments-and-divisions/immuno-oncology/javier-gordon-ogembo-lab
- To protect the health of patients and staff and to comply with new State of California mandates, City of Hope staff are required to show proof of full vaccination by September 30, 2021. Compliance is a condition of employment.
City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.
City of Hope is a community of people characterized by our diversity of thought, background and approach, but tied together by our commitment to care for and cure those with cancer and other life-threatening diseases. The innovation that our diversity produces in the areas of research, treatment, philanthropy and education has made us national leaders in this fight. Our unique and diverse workforce provides us the ability to understand our patients' needs, deliver compassionate care and continue the quest for a cure for life-threatening diseases. At City of Hope, diversity and inclusion is a core value at the heart of our mission. We strive to create an inclusive workplace environment that engages all of our employees and provides them with opportunities to develop and grow, both personally and professionally. Each day brings an opportunity to strengthen our work, leverage our different perspectives and improve our patients’ experiences by learning from others. Diversity and inclusion is about much more than policies and campaigns. It is an integral part of who we are as an institution, how we operate and how we see our future.