Postdoctoral Positions in Autoimmunity and Transplantation

University of Missouri, Columbia

Columbia, MO

Job posting number: #7085600

Posted: September 17, 2021

Application Deadline: Open Until Filled

Job Description

The Immunomodulation and Translational Research Program in the Department of Child Health, University of Missouri, Columbia, is seeking 3 Postdoctoral Fellows to participate in several federally-funded projects developing immunomodulatory approaches with applications to autoimmunity (type 1 diabetes), transplantation (bone marrow, islet, and heart transplantation), and cancer. The focus is on the development of novel biologics targeting pathways key to immune regulation. The efficacy of two biologics in inducing tolerance to allogeneic islet grafts for the treatment of type 1 diabetes have been demonstrated (Immunity 2002; Nature Materials 2018; Biomaterials 2019; Science Advances 2020, Journal of Immunology 2020; American Journal of Transplantation 2020) and a lead biologic is presently being pursued for clinical testing. The candidates for these positions will work on projects that use various platforms for targeted delivery of biologics for localized immunomodulation using various preclinical models for type 1 diabetes, bone marrow transplantation, graft-vs-Host disease, and allogeneic islet and heart transplantation. Key responsibilities include design and execution of experiments, data collection, analysis, interpretation, preparation for publications and presentations at national and international meetings. Successful candidates will have a strong immunology background with expertise in one or more following research areas: autoimmunity, islet transplantation, bone marrow transplantation, and graft-versus-host disease. Preference will be given to applicants who have extensive experience in tissue culture, humanized mouse models, pancreatic islet isolation and transplantation in mice, as well as strong hands-on expertise in immune cell functional assays, such as mixed lymphocytes reaction, deep immunophenotyping using flow cytometry. Expertise in molecular biology and recombinant protein expression and purification are desired but not required. Candidates must have strong skills in both verbal and written communications. Must be well organized, motivated, and can work effectively in a fast-paced team environment. Salary will be adhering to NIH salary guidelines, with an extensive benefits package.

Qualifications
This position requires Ph.D., M.D. or D.V.M. with a minimum of 3 years of basic laboratory experience and expertise in cellular immunology, basic molecular biology skills, tissue culture, and handling rodents.
Interested candidates should send their CV to Drs. Haval Shirwan (haval.shirwan@health.missouri.edu) or Esma S. Yolcu (esma.yolcu@health.missouri.edu).




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